Smoking impacts on the lives of children and young people throughout their childhood and vaping has increased amongst the Welsh population in recent years, with 8% of the adult population reporting they use them currently, and 5% of 11–16-year-olds using vapes at least weekly. This e-bulletin includes a range of articles which highlight national, regional or local initiatives, policies or programmes which focus on reducing inequalities in smoking, increasing the proportion of young children and young people who have a smoke-free childhood, and ensuring that there is a whole-system approach to a smoke-free Wales.